A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

<p>Abstract</p> <p>Background</p> <p>Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effects and tumor cell resis...

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Bibliographic Details
Main Authors: Martins Rafael M, Pesquero João B, Santos Edson L, Machado Joel, Silva Luis S, Pereira Felipe V, Rodrigues Tiago, Santana Débora P, Smaili Soraya S, Bechara Alexandre, Monteforte Priscila T, Matsuo Alisson L, Serrano Fabiana A, Travassos Luiz R, Caires Antonio CF, Rodrigues Elaine G
Format: Article
Language:English
Published: BMC 2011-07-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/11/296

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