Generation of a GLO-2 deficient mouse reveals its effects on liver carbonyl and glutathione levels

Generation of a GLO-2 deficient mouse reveals its effects on liver carbonyl and glutathione levels

Objective: Hydroxyacylglutathione hydrolase (aka as GLO-2) is a component of the glyoxalase pathway involved in the detoxification of the reactive oxoaldehydes, glyoxal and methylglyoxal. These reactive metabolites have been linked to a variety of pathological conditions, including diabetes, cancer...

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Bibliographic Details
Main Authors: Xingsheng Li, Sonia Fargue, Anil Kumar Challa, William Poore, John Knight, Kyle D. Wood
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Glyoxalase
Oxalate
Glutathione
Methylglyoxal
Glyoxal
d-lactate
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002326

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