DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study

DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study

An important bottleneck for non-viral gene transfer commonly relates to translocation of nucleic acids into the nuclear compartment of target cells. So-called 3NFs are optimized short nucleotide sequences able to interact with the transcription factor nuclear factor κB (NF-κB), which can enhance the...

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Bibliographic Details
Main Authors: Yann T. Le Guen, Chantal Pichon, Philippe Guégan, Kévin Pluchon, Tanguy Haute, Sandrine Quemener, Juliette Ropars, Patrick Midoux, Tony Le Gall, Tristan Montier
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hydrodynamic limb vein injection
NF-κB
nuclear import
plasmid DNA
skeletal muscle
transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000834

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