TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes

TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes

Background/Aims: Intracellular Ca2+ signaling plays an important role in the regulation of autophagy. However, very little is known about the role of Ca2+ influx, which is induced by plasma membrane Ca2+ channels. Our previous study showed that transient receptor potential canonical channel-6 (TRPC6...

Full description

Bibliographic Details
Main Authors:	Tianrong Ji, Chengwei Zhang, Linlin Ma, Qin Wang, Li Zou, Kexin Meng, Rui Zhang, Jundong Jiao
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Trpc6 Podocytes Autophagy Ca2+ signaling Adenosine monophosphate-activated protein kinase
Online Access:	https://www.karger.com/Article/FullText/492351

Similar Items

Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation
by: Lei Zhang, et al.
Published: (2017-10-01)

Diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes
by: Tae-Sun Ha, et al.
Published: (2014-03-01)

TRPC5 Channel Inhibition Protects Podocytes in Puromycin-Aminonucleoside Induced Nephrosis Models
by: Yiming Zhou, et al.
Published: (2021-09-01)

20-Hydroxyeicosatetraenoic acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes
by: Hila Roshanravan, et al.
Published: (2016-08-01)

Cytoskeleton Rearrangements Modulate TRPC6 Channel Activity in Podocytes
by: Alexey Shalygin, et al.
Published: (2021-04-01)

Inhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1
by: Haiting Huang, et al.
Published: (2017-01-01)

Alpha1-Adrenergic Receptor Activation Stimulates Calcium Entry and Proliferation via TRPC6 Channels in Cultured Human Mesangial Cells
by: Fanwu Kong, et al.
Published: (2015-07-01)

Penicilliumin B Protects against Cisplatin-Induced Renal Tubular Cell Apoptosis through Activation of AMPK-Induced Autophagy and Mitochondrial Biogenesis
by: Weiwei Shen, et al.
Published: (2021-04-01)

Podocyte Autophagy in Homeostasis and Disease
by: Qisheng Lin, et al.
Published: (2021-03-01)

The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis
by: Hai-Tao Zhang, et al.
Published: (2016-12-01)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
by: Xueling Li, et al.
Published: (2020-02-01)

The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries
by: Xin Hou, et al.
Published: (2021-07-01)

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons
by: Frauke Kepura, et al.
Published: (2020-02-01)

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia
by: Ying Yu, et al.
Published: (2018-10-01)

Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling
by: Juan Jin, et al.
Published: (2018-07-01)

Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels
by: Stuart E. Dryer, et al.
Published: (2018-08-01)

Catalpol Ameliorates Podocyte Injury by Stabilizing Cytoskeleton and Enhancing Autophagy in Diabetic Nephropathy
by: Yan Chen, et al.
Published: (2019-12-01)

Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy
by: Qi Yu, et al.
Published: (2019-01-01)

Vitamin D/VDR Protects Against Diabetic Kidney Disease by Restoring Podocytes Autophagy
by: Song Z, et al.
Published: (2021-04-01)

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels
by: Michael Mederos y Schnitzler, et al.
Published: (2018-11-01)

TRPC1/5-CaV3 Complex Mediates Leptin-Induced Excitability in Hypothalamic Neurons
by: Paula P. Perissinotti, et al.
Published: (2021-06-01)

Transient Receptor Potential Canonical (TRPC) Channels: Then and Now
by: Xingjuan Chen, et al.
Published: (2020-08-01)

TRPC Channels: Dysregulation and Ca<sup>2+</sup> Mishandling in Ischemic Heart Disease
by: Débora Falcón, et al.
Published: (2020-01-01)

Role of TRPC1 channels in pressure-mediated activation of airway remodeling
by: Na Li, et al.
Published: (2019-05-01)

Cooperative strategies in the UWB TRPC networks
by: Dong, Xue
Published: (2011)

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy
by: Caroline Sunggip, et al.
Published: (2018-05-01)

ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
by: Shizhu Yuan, et al.
Published: (2021-01-01)

Autophagy activity and expression pattern of autophagy-related markers in the podocytes of patients with lupus nephritis: association with pathological classification
by: Juan Jin, et al.
Published: (2019-01-01)

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors
by: Kangcheng Song, et al.
Published: (2021-03-01)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
by: D Dutta, et al.
Published: (2017-01-01)

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
by: X. Julia Xu, et al.
Published: (2012-04-01)

Effect of adenosine monophosphate‐activated protein kinase–p53–Krüppel‐like factor 2a pathway in hyperglycemia‐induced cardiac remodeling in adult zebrafish
by: Qiuyun Wang, et al.
Published: (2021-03-01)

The Involvement of TRPC3 channels in Sinoatrial Arrhythmias
by: Yue-Kun eJu, et al.
Published: (2015-03-01)

Rapamycin Induces Autophagy and Reduces the Apoptosis of Podocytes Under a Stimulated Condition of Immunoglobulin A Nephropathy
by: Shikai Liang, et al.
Published: (2017-04-01)

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice
by: Anne-Emilie Declèves, et al.
Published: (2019-05-01)

Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro
by: Xue Gao, et al.
Published: (2020-09-01)

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway[S]
by: Yun Li, et al.
Published: (2019-04-01)

Angiotensin-II-Evoked Ca<sup>2+</sup> Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
by: Juan E. Camacho Londoño, et al.
Published: (2020-01-01)

The Expression Profile of Complement Components in Podocytes
by: Xuejuan Li, et al.
Published: (2016-03-01)

Impaired nicotinamide adenine dinucleotide (NAD+) metabolism in diabetes and diabetic tissues: Implications for nicotinamide‐related compound treatment
by: Lan Fan, et al.
Published: (2020-11-01)