Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2

Therapeutic anti-HER2 antibodies and antibody–drug conjugates (ADCs) have undoubtedly benefitted patients. Nonetheless, patients ultimately relapse—some sooner than others. Currently approved anti-HER2 drugs are expensive and their cost-effectiveness is debated. There is increased awareness that int...

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Bibliographic Details
Main Author: Jeffrey V. Leyton
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antibodies
Subjects:
Online Access:https://www.mdpi.com/2073-4468/9/3/32