Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?

Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?

Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the proces...

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Bibliographic Details
Main Authors: Ahmed Abdelhak, Andreas Junker, Johannes Brettschneider, Jan Kassubek, Albert C. Ludolph, Markus Otto, Hayrettin Tumani
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
primary progressive multiple sclerosis (PPMS)
amyotrophic lateral sclerosis (ALS)
neurofilaments
biomarker
tau
tubulin
Online Access:http://www.mdpi.com/1422-0067/16/8/17565

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