Life times of metastable states guide regulatory signaling in transcriptional riboswitches
Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and k...
Main Authors: | Christina Helmling, Dean-Paulos Klötzner, Florian Sochor, Rachel Anne Mooney, Anna Wacker, Robert Landick, Boris Fürtig, Alexander Heckel, Harald Schwalbe |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03375-w |
Similar Items
-
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
by: Hannah Steinert, et al.
Published: (2017-05-01) -
Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
by: Vanessa de Jesus, et al.
Published: (2021-08-01) -
Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms.
by: Jean-François Lemay, et al.
Published: (2011-01-01) -
Regulatory context drives conservation of glycine riboswitch aptamers.
by: Matt Crum, et al.
Published: (2019-12-01) -
Design principles for riboswitch function.
by: Chase L Beisel, et al.
Published: (2009-04-01)