Life times of metastable states guide regulatory signaling in transcriptional riboswitches

Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and k...

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Main Authors:	Christina Helmling, Dean-Paulos Klötzner, Florian Sochor, Rachel Anne Mooney, Anna Wacker, Robert Landick, Boris Fürtig, Alexander Heckel, Harald Schwalbe
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03375-w

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spelling	doaj-cba69ad002cb4eff9de91d08453313112021-05-11T09:51:32ZengNature Publishing GroupNature Communications2041-17232018-03-01911910.1038/s41467-018-03375-wLife times of metastable states guide regulatory signaling in transcriptional riboswitchesChristina Helmling0Dean-Paulos Klötzner1Florian Sochor2Rachel Anne Mooney3Anna Wacker4Robert Landick5Boris Fürtig6Alexander Heckel7Harald Schwalbe8Institute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-UniversitätInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University FrankfurtInstitute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-UniversitätDepartment of Biochemistry, University of Wisconsin–MadisonInstitute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-UniversitätDepartment of Biochemistry, University of Wisconsin–MadisonInstitute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-UniversitätInstitute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University FrankfurtInstitute for Organic Chemistry and Chemical Biology Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-UniversitätRiboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and kinetic on- and off-rates of ligand binding.https://doi.org/10.1038/s41467-018-03375-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe
spellingShingle	Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe Life times of metastable states guide regulatory signaling in transcriptional riboswitches Nature Communications
author_facet	Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe
author_sort	Christina Helmling
title	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_short	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_full	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_fullStr	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_full_unstemmed	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_sort	life times of metastable states guide regulatory signaling in transcriptional riboswitches
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and kinetic on- and off-rates of ligand binding.
url	https://doi.org/10.1038/s41467-018-03375-w
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Life times of metastable states guide regulatory signaling in transcriptional riboswitches

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