The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus

The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus

Abstract Background We recently reported on the enhanced tubular expression of two discrete isoforms of the MMP-2 (full length and N-terminal truncated, FL-MMP-2, NTT-MMP-2) in a murine model and human diabetic kidneys. In the present study, we examined in more detail the temporal and spatial distri...

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Bibliographic Details
Main Authors: Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett, Sang Heon Song
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Nephrology
Subjects:
Diabetes mellitus
Hyperglycemia
Matrix metalloproteinase-2
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12882-018-1029-8

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