Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.

Bibliographic Details
Main Authors: Mausita Karmakar, Michael A. Katsnelson, George R. Dubyak, Eric Pearlman
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10555
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spelling doaj-cb95f200ea844722806edee650b3641b2021-05-11T11:14:44ZengNature Publishing GroupNature Communications2041-17232016-02-017111310.1038/ncomms10555Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATPMausita Karmakar0Michael A. Katsnelson1George R. Dubyak2Eric Pearlman3Department of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Physiology and Biophysics, Case Western Reserve UniversityDepartment of Ophthalmology and Visual Sciences, Case Western Reserve UniversityNeutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.https://doi.org/10.1038/ncomms10555
collection DOAJ
language English
format Article
sources DOAJ
author Mausita Karmakar
Michael A. Katsnelson
George R. Dubyak
Eric Pearlman
spellingShingle Mausita Karmakar
Michael A. Katsnelson
George R. Dubyak
Eric Pearlman
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Nature Communications
author_facet Mausita Karmakar
Michael A. Katsnelson
George R. Dubyak
Eric Pearlman
author_sort Mausita Karmakar
title Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_short Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_full Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_fullStr Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_full_unstemmed Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_sort neutrophil p2x7 receptors mediate nlrp3 inflammasome-dependent il-1β secretion in response to atp
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.
url https://doi.org/10.1038/ncomms10555
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AT michaelakatsnelson neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp
AT georgerdubyak neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp
AT ericpearlman neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp
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