PPARs in Irradiation-Induced Gastrointestinal Toxicity

PPARs in Irradiation-Induced Gastrointestinal Toxicity

The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and...

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Main Authors: Christine Linard, Maâmar Souidi
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/528327
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spelling doaj-cb92a8ed16d4429a932abcfdbcd5ba6f2020-11-25T01:06:41ZengHindawi LimitedPPAR Research1687-47571687-47652010-01-01201010.1155/2010/528327528327PPARs in Irradiation-Induced Gastrointestinal ToxicityChristine Linard0Maâmar Souidi1Institute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, FranceInstitute for Radioprotection and Nuclear Safety, B.P. no.17, 92262 Fontenay aux Roses Cedex, FranceThe use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection.http://dx.doi.org/10.1155/2010/528327
collection DOAJ
language English
format Article
sources DOAJ
author Christine Linard
Maâmar Souidi
spellingShingle Christine Linard
Maâmar Souidi
PPARs in Irradiation-Induced Gastrointestinal Toxicity
PPAR Research
author_facet Christine Linard
Maâmar Souidi
author_sort Christine Linard
title PPARs in Irradiation-Induced Gastrointestinal Toxicity
title_short PPARs in Irradiation-Induced Gastrointestinal Toxicity
title_full PPARs in Irradiation-Induced Gastrointestinal Toxicity
title_fullStr PPARs in Irradiation-Induced Gastrointestinal Toxicity
title_full_unstemmed PPARs in Irradiation-Induced Gastrointestinal Toxicity
title_sort ppars in irradiation-induced gastrointestinal toxicity
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2010-01-01
description The use of radiation therapy to treat cancer inevitably involves exposure of normal tissues. Although the benefits of this treatment are well established, many patients experience distressing complications due to injury to normal tissue. These side effects are related to inflammatory processes, and they decrease therapeutic benefit by increasing the overall treatment time. Emerging evidence indicates that PPARs and their ligands are important in the modulation of immune and inflammatory reactions. This paper discusses the effects of abdominal irradiation on PPARs, their role and functions in irradiation toxicity, and the possibility of using their ligands for radioprotection.
url http://dx.doi.org/10.1155/2010/528327
work_keys_str_mv AT christinelinard pparsinirradiationinducedgastrointestinaltoxicity
AT maamarsouidi pparsinirradiationinducedgastrointestinaltoxicity
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