Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B

Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B

Abstract The effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus. The findings indicated that capric acid may be a promising additive for use in combi...

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Main Authors: Jakub Suchodolski, Daria Derkacz, Przemysław Bernat, Anna Krasowska
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86012-9
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spelling doaj-cb82ebae75d74fe2a63e0208428fe0952021-03-28T11:32:50ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111010.1038/s41598-021-86012-9Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin BJakub Suchodolski0Daria Derkacz1Przemysław Bernat2Anna Krasowska3Department of Biotransformation, Faculty of Biotechnology, University of WroclawDepartment of Biotransformation, Faculty of Biotechnology, University of WroclawDepartment of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of ŁódźDepartment of Biotransformation, Faculty of Biotechnology, University of WroclawAbstract The effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus. The findings indicated that capric acid may be a promising additive for use in combination with FLC. A FLC-capric acid combination led to reduced efflux activity of multidrug resistance (MDR) transporter Cdr1p by causing it to relocalize from the plasma membrane (PM) to the interior of the cell. The above effect occurred due to inhibitory effect of FLC-capric acid combination of ergosterol biosynthesis. However, capric acid alone stimulated ergosterol production in C. albicans, which in turn generated cross resistance towards AMB and inhibited its action (PM permeabilization and cytoplasm leakage) against C. albicans cells. This concluded that AMB should not be administered among dietary supplements containing capric acid or S. boulardii cells.https://doi.org/10.1038/s41598-021-86012-9
collection DOAJ
language English
format Article
sources DOAJ
author Jakub Suchodolski
Daria Derkacz
Przemysław Bernat
Anna Krasowska
spellingShingle Jakub Suchodolski
Daria Derkacz
Przemysław Bernat
Anna Krasowska
Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
Scientific Reports
author_facet Jakub Suchodolski
Daria Derkacz
Przemysław Bernat
Anna Krasowska
author_sort Jakub Suchodolski
title Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
title_short Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
title_full Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
title_fullStr Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
title_full_unstemmed Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B
title_sort capric acid secreted by saccharomyces boulardii influences the susceptibility of candida albicans to fluconazole and amphotericin b
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2021-03-01
description Abstract The effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus. The findings indicated that capric acid may be a promising additive for use in combination with FLC. A FLC-capric acid combination led to reduced efflux activity of multidrug resistance (MDR) transporter Cdr1p by causing it to relocalize from the plasma membrane (PM) to the interior of the cell. The above effect occurred due to inhibitory effect of FLC-capric acid combination of ergosterol biosynthesis. However, capric acid alone stimulated ergosterol production in C. albicans, which in turn generated cross resistance towards AMB and inhibited its action (PM permeabilization and cytoplasm leakage) against C. albicans cells. This concluded that AMB should not be administered among dietary supplements containing capric acid or S. boulardii cells.
url https://doi.org/10.1038/s41598-021-86012-9
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