GSK-3beta controls osteogenesis through regulating Runx2 activity.

GSK-3beta controls osteogenesis through regulating Runx2 activity.

Despite accumulated knowledge of various signalings regulating bone formation, the molecular network has not been clarified sufficiently to lead to clinical application. Here we show that heterozygous glycogen synthase kinase-3beta (GSK-3beta)-deficient mice displayed an increased bone formation due...

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Bibliographic Details
Main Authors: Fumitaka Kugimiya, Hiroshi Kawaguchi, Shinsuke Ohba, Naohiro Kawamura, Makoto Hirata, Hirotaka Chikuda, Yoshiaki Azuma, James R Woodgett, Kozo Nakamura, Ung-il Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1950686?pdf=render

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