Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility.

Bibliographic Details
Main Authors:	Mariana L. Stevens, Zhonghua Zhang, Elisabet Johansson, Samriddha Ray, Amrita Jagpal, Brandy P. Ruff, Arjun Kothari, Hua He, Lisa J. Martin, Hong Ji, Kathryn Wikenheiser-Brokamp, Matthew T. Weirauch, Dorothy M. Supp, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17895-x

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spelling	doaj-cb73b4e6acf04165bd138a7fc4b88cd62021-08-15T11:41:50ZengNature Publishing GroupNature Communications2041-17232020-08-0111111010.1038/s41467-020-17895-xDisease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis riskMariana L. Stevens0Zhonghua Zhang1Elisabet Johansson2Samriddha Ray3Amrita Jagpal4Brandy P. Ruff5Arjun Kothari6Hua He7Lisa J. Martin8Hong Ji9Kathryn Wikenheiser-Brokamp10Matthew T. Weirauch11Dorothy M. Supp12Jocelyn M. Biagini Myers13Gurjit K. Khurana Hershey14Division of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Human Genetics, Cincinnati Children’s Hospital Medical CenterDivision of Human Genetics, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineResearch Department, Shriners Hospitals for ChildrenDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterDivision of Asthma Research, Cincinnati Children’s Hospital Medical CenterGenetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility.https://doi.org/10.1038/s41467-020-17895-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey
spellingShingle	Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk Nature Communications
author_facet	Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey
author_sort	Mariana L. Stevens
title	Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
title_short	Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
title_full	Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
title_fullStr	Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
title_full_unstemmed	Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
title_sort	disease-associated kif3a variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility.
url	https://doi.org/10.1038/s41467-020-17895-x
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Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

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