A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conserved Shh enhancer SBE2 (Shh brain enhancer 2) in mouse markedly reduced Shh expression within the embryonic brain specifically in the rostral die...

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Bibliographic Details
Main Authors: Zoe Crane-Smith, Jeffrey Schoenebeck, Katy A. Graham, Paul S. Devenney, Lorraine Rose, Mark Ditzell, Eve Anderson, Joseph I. Thomson, Natasha Klenin, Deborah M. Kurrasch, Laura A. Lettice, Robert E. Hill
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Shh
enhancer
hypothalamic development
craniofacial formation
embryonic development
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.595744/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.595744/full

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