The importance of RET-He in the diagnosis of iron deficiency and iron deficiency anemia and the evaluation of response to oral iron therapy

• Main Authors: Ali-Uçar Mehmet, Falay Mesude, Dagdas Simten, Ceran Funda, Merih-Urlu Selin, Gülsüm Ozet
• Format: Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 2019-01-01
• Series: Journal of Medical Biochemistry
• Subjects: reticulocyte hemoglobin equivalent (ret-he); iron deficiency anemia (ida); iron
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581904496A.pdf

Background: The purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RETHe) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient's response to oral iron treatment. M ethods: The research population consisted of 217 participants in total: 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of < 130.0 g/L was defined as indicating anemia for men, while an Hb value of < 120.0 g/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily. Results: The RET-He was significantly lower in the IDA group, compared to other groups (IDA: 21.0 ± 4.1, ID: 26.0 ± 4.9, non-ID anemia: 32.1 ± 6.8, control: 36.6 ± 7.0; < 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group. Conclusions: The results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.