Study of the effect of prostaglandin F2α analogue, Dinoprost, on cropus luteal tissue in pseudopregnant rabbit

• Main Authors: S.e Safavi, M.H Khayat Nouri
• Format: Article
• Language: fas
• Published: Islamic Azad University, Tabriz Branch 2008-05-01
• Series: Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī
• Subjects: PGF2 alpha; corpus luteum; pseudopregnancy; Rabbit
• Online Access: http://jvcp.iaut.ac.ir/article_518594_02b3309475350869b4edc99a10aa8cad.pdf

In this study the effect of prostaglandin F2 alpha analogue, dinoprost, on corpus luteal tissue in pseudopregnant rabbit was investigated. For this purpose, 42 mature female rabbits were randomly divided into 6 groups of 7 animals each. In 3 groups, on day 10 of pseudopregnancy, dinoprost (1mg/kg) was injected intramuscularly and 24, 48 and 72 hours following injection respectively, the animals were necropsied. In the other three groups, normal saline solution was injected as control groups. In all groups, after blood sampling the animals were necropsied and their ovaries removed and weighed. Following sampling and fixation in 10% formalin solution, the tissue samples were stained by Hematoxylene & Eosine method and the corpora lutea were studied morphologically and morphometrically. Histomorphometrical study indicated that the diameter of corpus luteum decreased significantly (p