Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype
The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04179-8 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee |
| spellingShingle |
Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype Nature Communications |
| author_facet |
Sang Cheul Oh Bo Hwa Sohn Jae-Ho Cheong Sang-Bae Kim Jae Eun Lee Ki Cheong Park Sang Ho Lee Jong-Lyul Park Yun-Yong Park Hyun-Sung Lee Hee-Jin Jang Eun Sung Park Sang-Cheol Kim Jeonghoon Heo In-Sun Chu You-Jin Jang Young-Jae Mok WonKyung Jung Baek-Hui Kim Aeree Kim Jae Yong Cho Jae Yun Lim Yuki Hayashi Shumei Song Elena Elimova Jeannelyn S. Estralla Jeffrey H. Lee Manoop S. Bhutani Yiling Lu Wenbin Liu Jeeyun Lee Won Ki Kang Sung Kim Sung Hoon Noh Gordon B. Mills Seon-Young Kim Jaffer A. Ajani Ju-Seog Lee |
| author_sort |
Sang Cheul Oh |
| title |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_short |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_full |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_fullStr |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_full_unstemmed |
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| title_sort |
clinical and genomic landscape of gastric cancer with a mesenchymal phenotype |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-05-01 |
| description |
The prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy. |
| url |
https://doi.org/10.1038/s41467-018-04179-8 |
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1721448550575898624 |
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doaj-cb4f389472124edeb3126b20dcd9ed152021-05-11T10:13:59ZengNature Publishing GroupNature Communications2041-17232018-05-019111410.1038/s41467-018-04179-8Clinical and genomic landscape of gastric cancer with a mesenchymal phenotypeSang Cheul Oh0Bo Hwa Sohn1Jae-Ho Cheong2Sang-Bae Kim3Jae Eun Lee4Ki Cheong Park5Sang Ho Lee6Jong-Lyul Park7Yun-Yong Park8Hyun-Sung Lee9Hee-Jin Jang10Eun Sung Park11Sang-Cheol Kim12Jeonghoon Heo13In-Sun Chu14You-Jin Jang15Young-Jae Mok16WonKyung Jung17Baek-Hui Kim18Aeree Kim19Jae Yong Cho20Jae Yun Lim21Yuki Hayashi22Shumei Song23Elena Elimova24Jeannelyn S. Estralla25Jeffrey H. Lee26Manoop S. Bhutani27Yiling Lu28Wenbin Liu29Jeeyun Lee30Won Ki Kang31Sung Kim32Sung Hoon Noh33Gordon B. Mills34Seon-Young Kim35Jaffer A. Ajani36Ju-Seog Lee37Department of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Surgery, Yonsei University College of MedicineDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Surgery, Yonsei University College of MedicineDepartment of Surgery, Yonsei University College of MedicineDepartment of Surgery, Kosin University, College of MedicinePersonalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Medicine, ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of MedicineDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterMedical Research Institute, College of Medicine, Inha UniversityDepartment of Biomedical Informatics, Center for Genome Science, National Institute of HealthDepartment of Molecular Biology and Immunology, Kosin University, College of MedicineKorean Bioinformation Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Surgery, Guro Hospital, College of Medicine, Korea UniversityDepartment of Surgery, Guro Hospital, College of Medicine, Korea UniversityDepartment of Surgery, Guro Hospital, College of Medicine, Korea UniversityDepartment of Pathology, Guro Hospital, College of Medicine, Korea UniversityDepartment of Pathology, Guro Hospital, College of Medicine, Korea UniversityMedical Oncology, Yonsei University College of MedicineMedical Oncology, Yonsei University College of MedicineDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Medicine, Samsung Medical Center, Division of Hematology-OncologyDepartment of Medicine, Samsung Medical Center, Division of Hematology-OncologyDepartment of Surgery, Samsung Medical CenterDepartment of Surgery, Yonsei University College of MedicineDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterPersonalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and BiotechnologyDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterThe prognosis and treatment of gastric cancer is complicated by heterogeneity. Here, the authors reveal two molecular subtypes, the mesenchymal subtype associated with poor survival and chemoresistance, and the epithelial phenotype associated with better survival and sensitivity to chemotherapy.https://doi.org/10.1038/s41467-018-04179-8 |