A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.

A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy.

Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogene...

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Bibliographic Details
Main Authors: Ana C Xavier, Holly Edwards, Alan A Dombkowski, Tugce B Balci, Jason N Berman, Graham Dellaire, Chengzhi Xie, Steven A Buck, Larry H Matherly, Yubin Ge, Jeffrey W Taub
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3217966?pdf=render

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http://europepmc.org/articles/PMC3217966?pdf=render

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