Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.
Bibliographic Details
| Main Authors: |
Matteo Spinelli,
Salvatore Fusco,
Marco Mainardi,
Federico Scala,
Francesca Natale,
Rosita Lapenta,
Andrea Mattera,
Marco Rinaudo,
Domenica Donatella Li Puma,
Cristian Ripoli,
Alfonso Grassi,
Marcello D’Ascenzo,
Claudio Grassi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02221-9
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