Regulatory Role of Cell Division Rules on Tissue Growth Heterogeneity

• Main Authors: Karen Alim, Olivier Hamant, Arezki Boudaoud
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2012-08-01
• Series: Frontiers in Plant Science
• Subjects: growth regulation; stochasticity; morphogenesis; mechanical forces; vertex model; cell division
• Online Access: https://www.frontiersin.org/article/10.3389/fpls.2012.00174/full

The coordination of cell division and cell expansion are critical to normal development of tissues. In plants, cell wall mechanics and the there from arising cell shapes and mechanical stresses can regulate cell division and cell expansion and thereby tissue growth and morphology. Limited by experimental accessibility it remains unknown how cell division and expansion cooperatively affect tissue growth dynamics. Employing a cell-based two dimensional tissue simulation we investigate the regulatory role of a range of cell division rules on tissue growth dynamics and in particular on the spatial heterogeneity of growth. We find that random cell divisions only add noise to the growth and therefore increase growth heterogeneity, while cell divisions following the shortest new wall or along the direction of maximal mechanical stress reduce growth heterogeneity by actively enhancing the regulation of growth by mechanical stresses. Thus, we find that, beyond tissue geometry and topology, cell divisions affect the dynamics of growth, and that their signature is embedded in the statistics of tissue growth.