Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49

Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49

Two novel altenusin-thiazole hybrids named altenusinoides A and B (<b>1</b> and <b>2</b>), a new benzothiazole derivative (<b>3</b>), and three known altenusin derivatives (<b>4</b>&#8315;<b>6</b>) have been obtained from the solid cult...

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Main Authors: Yaping Chen, Ruyan Chen, Jinhuai Xu, Yongqi Tian, Jiangping Xu, Yonghong Liu
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
sponge-derived fungus
<i>Alternaria</i> sp. SCSIOS02F49
altenusin/thiazole hybrids
benzothiazole derivative
Online Access:https://www.mdpi.com/1420-3049/23/11/2844
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spelling doaj-cb3e46ad502b4151a210aebafa64cccb2020-11-25T00:50:43ZengMDPI AGMolecules1420-30492018-11-012311284410.3390/molecules23112844molecules23112844Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49Yaping Chen0Ruyan Chen1Jinhuai Xu2Yongqi Tian3Jiangping Xu4Yonghong Liu5School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, ChinaCollege of Biological Science and Technology, Fuzhou University, Fuzhou 350116, ChinaCollege of Biological Science and Technology, Fuzhou University, Fuzhou 350116, ChinaCollege of Biological Science and Technology, Fuzhou University, Fuzhou 350116, ChinaSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaTwo novel altenusin-thiazole hybrids named altenusinoides A and B (<b>1</b> and <b>2</b>), a new benzothiazole derivative (<b>3</b>), and three known altenusin derivatives (<b>4</b>&#8315;<b>6</b>) have been obtained from the solid culture of the marine sponge-derived fungal strain, <i>Alternaria</i> sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds <b>1</b> and <b>2</b> possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound <b>3</b> represents the first benzothiazole derivative from fungi. Compounds <b>4</b> and <b>5</b> showed significant DPPH free-radical-scavenging activities with the prominent IC<sub>50</sub> values of 10.7 &#177; 0.09 &#956;M and 100.6 &#177; 0.025 &#956;M, respectively. Additionally, compound <b>5</b> exhibited COX-2 inhibitory activity with an IC<sub>50</sub> value of 9.5 &#177; 0.08 &#956;M.https://www.mdpi.com/1420-3049/23/11/2844sponge-derived fungus<i>Alternaria</i> sp. SCSIOS02F49altenusin/thiazole hybridsbenzothiazole derivative
collection DOAJ
language English
format Article
sources DOAJ
author Yaping Chen
Ruyan Chen
Jinhuai Xu
Yongqi Tian
Jiangping Xu
Yonghong Liu
spellingShingle Yaping Chen
Ruyan Chen
Jinhuai Xu
Yongqi Tian
Jiangping Xu
Yonghong Liu
Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
Molecules
sponge-derived fungus
<i>Alternaria</i> sp. SCSIOS02F49
altenusin/thiazole hybrids
benzothiazole derivative
author_facet Yaping Chen
Ruyan Chen
Jinhuai Xu
Yongqi Tian
Jiangping Xu
Yonghong Liu
author_sort Yaping Chen
title Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
title_short Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
title_full Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
title_fullStr Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
title_full_unstemmed Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus <i>Alternaria</i> sp. SCSIOS02F49
title_sort two new altenusin/thiazole hybrids and a new benzothiazole derivative from the marine sponge-derived fungus <i>alternaria</i> sp. scsios02f49
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2018-11-01
description Two novel altenusin-thiazole hybrids named altenusinoides A and B (<b>1</b> and <b>2</b>), a new benzothiazole derivative (<b>3</b>), and three known altenusin derivatives (<b>4</b>&#8315;<b>6</b>) have been obtained from the solid culture of the marine sponge-derived fungal strain, <i>Alternaria</i> sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds <b>1</b> and <b>2</b> possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound <b>3</b> represents the first benzothiazole derivative from fungi. Compounds <b>4</b> and <b>5</b> showed significant DPPH free-radical-scavenging activities with the prominent IC<sub>50</sub> values of 10.7 &#177; 0.09 &#956;M and 100.6 &#177; 0.025 &#956;M, respectively. Additionally, compound <b>5</b> exhibited COX-2 inhibitory activity with an IC<sub>50</sub> value of 9.5 &#177; 0.08 &#956;M.
topic sponge-derived fungus
<i>Alternaria</i> sp. SCSIOS02F49
altenusin/thiazole hybrids
benzothiazole derivative
url https://www.mdpi.com/1420-3049/23/11/2844
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