Genetic polymorphism of CYP2C8*4 in a healthy Turkish population

Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds. Single nucleotide polymorphisms in CYP2C8 gene may change CYP2C8 enzyme activity and therefore may affect the adverse reactions and efficacy of dr...

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Main Author: Zuhal Uckun Sahinogullari
Format: Article
Language:English
Published: Society of TURAZ AKADEMI 2020-06-01
Series:Medicine Science
Subjects:
Online Access:http://www.ejmanager.com/fulltextpdf.php?mno=77098
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spelling doaj-cb3be380b5cc4c998ff8a41312ad0a652021-03-24T11:49:41ZengSociety of TURAZ AKADEMI Medicine Science2147-06342020-06-0192314910.5455/medscience.2019.08.918977098Genetic polymorphism of CYP2C8*4 in a healthy Turkish populationZuhal Uckun Sahinogullari0Mersin University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Mersin, TurkeyCytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds. Single nucleotide polymorphisms in CYP2C8 gene may change CYP2C8 enzyme activity and therefore may affect the adverse reactions and efficacy of drugs metabolized by this. The purpose of the current investigation was to detect the genotype and allele frequencies of CYP2C8*4 in a healthy Turkish population and also to compare our findings with the other populations. CYP2C8*4 polymorphism was analyzed by polymerase chain reaction-restriction fragment length method using DNA samples isolated from 109 healthy Turkish volunteers. The genotype frequencies were 95.4% for the homozygous wild-type, 4.6% for heterozygous and 0.0 % for homozygous variant. According to this, the frequencies of wild type and variant alleles were determined as 0.977 and 0.023, respectively. The genotype frequencies did not deviate from the Hardy-Weinberg equilibrium. Significant population differences were observed when the findings were compared with those of other populations. This is the first investigation to examine the frequencies of CYP2C8*4 polymorphism in Turkish population. The determination of CYP2C8*4 polymorphism may provide useful data about the pharmacokinetics, efficacy and/or toxicity of its substrates and predisposition to some diseases and may help to improve personalized therapy in the future and also contributes to epidemiological studies. [Med-Science 2020; 9(2.000): 314-9]http://www.ejmanager.com/fulltextpdf.php?mno=77098cyp2c8genetic polymorphismdrug metabolismturkish population
collection DOAJ
language English
format Article
sources DOAJ
author Zuhal Uckun Sahinogullari
spellingShingle Zuhal Uckun Sahinogullari
Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
Medicine Science
cyp2c8
genetic polymorphism
drug metabolism
turkish population
author_facet Zuhal Uckun Sahinogullari
author_sort Zuhal Uckun Sahinogullari
title Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
title_short Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
title_full Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
title_fullStr Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
title_full_unstemmed Genetic polymorphism of CYP2C8*4 in a healthy Turkish population
title_sort genetic polymorphism of cyp2c8*4 in a healthy turkish population
publisher Society of TURAZ AKADEMI
series Medicine Science
issn 2147-0634
publishDate 2020-06-01
description Cytochrome P4502C8 (CYP2C8) is a significant member of CYP enzyme family and metabolizes about 20% of commonly prescribed drugs and endogenous compounds. Single nucleotide polymorphisms in CYP2C8 gene may change CYP2C8 enzyme activity and therefore may affect the adverse reactions and efficacy of drugs metabolized by this. The purpose of the current investigation was to detect the genotype and allele frequencies of CYP2C8*4 in a healthy Turkish population and also to compare our findings with the other populations. CYP2C8*4 polymorphism was analyzed by polymerase chain reaction-restriction fragment length method using DNA samples isolated from 109 healthy Turkish volunteers. The genotype frequencies were 95.4% for the homozygous wild-type, 4.6% for heterozygous and 0.0 % for homozygous variant. According to this, the frequencies of wild type and variant alleles were determined as 0.977 and 0.023, respectively. The genotype frequencies did not deviate from the Hardy-Weinberg equilibrium. Significant population differences were observed when the findings were compared with those of other populations. This is the first investigation to examine the frequencies of CYP2C8*4 polymorphism in Turkish population. The determination of CYP2C8*4 polymorphism may provide useful data about the pharmacokinetics, efficacy and/or toxicity of its substrates and predisposition to some diseases and may help to improve personalized therapy in the future and also contributes to epidemiological studies. [Med-Science 2020; 9(2.000): 314-9]
topic cyp2c8
genetic polymorphism
drug metabolism
turkish population
url http://www.ejmanager.com/fulltextpdf.php?mno=77098
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