Sestrin2 protects against bavachin induced ER stress through AMPK/mTORC1 signaling pathway in HepG2 cells

Sestrin2 protects against bavachin induced ER stress through AMPK/mTORC1 signaling pathway in HepG2 cells

Bavachin (BV), a natural flavonoid compound derived from Psoralea corylifolia L, has been reported to be a potential hepatotoxin. Our previous studies have found that BV can induce endoplasmic reticulum (ER) stress-related cell apoptosis, but the molecular mechanism underlying BV-induced ER stress r...

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Bibliographic Details
Main Authors: Ying Yang, Guiming Guo, Wei Zhou, Yunxuan Ge, Zheng Fan, Qingquan Liu, Yue Gao
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Bavachin
Acute liver injury
Sestrin2
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320301183

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