A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics–Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate

A Microdialysis in Adjuvant Arthritic Rats for Pharmacokinetics–Pharmacodynamics Modeling Study of Geniposide with Determination of Drug Concentration and Efficacy Levels in Dialysate

Microdialysis, a sampling method for pharmacokinetics–pharmacodynamics (PK–PD) modeling in preclinical and clinical studies, is a convenient in vivo sampling technique. Geniposide (GE), an iridoid glycoside compound, is the major active ingredient of Gardenia jasminoides Ellis fruit which has an ant...

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Bibliographic Details
Main Authors: Ran Deng, Wei Wang, Hong Wu, Yunjing Zhang, Wenyu Wang, Li Dai, Zhengrong Zhang, Jun Fu, Feng Li
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
rheumatoid arthritis
microdialysis
geniposide
PK–PD modeling
prostaglandin E2
UHPLC-MS/MS
Online Access:http://www.mdpi.com/1420-3049/23/5/987

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