Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing

Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing

Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. The A9 DA neuron subtype controls motor function...

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Bibliographic Details
Main Authors: Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar, Petter Storm
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
human pluripotent stem cells
dopamine neuron differentiation
Parkinson’s disease
human brain organoids
cell transplantation
single cell RNA sequencing
Online Access:https://www.mdpi.com/2073-4409/10/6/1366

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