IL-17 in the Rheumatologist’s Line of Sight
Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation...
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2013-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/295132 |
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doaj-cb28b5c1dd5c4f228af4ba1c99c52dc92020-11-25T00:10:16ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/295132295132IL-17 in the Rheumatologist’s Line of SightMarie-Elise Truchetet0M. Djavad Mossalayi1Katia Boniface2UMR-CNRS 5164, Composantes Innées de la Réponse Immunitaire et de la Différenciation, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux, FranceINSERM U1035–Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux, FranceINSERM U1035–Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen, 146 rue Léo Saignat, 33076 Bordeaux, FranceOver the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis. Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed.http://dx.doi.org/10.1155/2013/295132 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marie-Elise Truchetet M. Djavad Mossalayi Katia Boniface |
| spellingShingle |
Marie-Elise Truchetet M. Djavad Mossalayi Katia Boniface IL-17 in the Rheumatologist’s Line of Sight BioMed Research International |
| author_facet |
Marie-Elise Truchetet M. Djavad Mossalayi Katia Boniface |
| author_sort |
Marie-Elise Truchetet |
| title |
IL-17 in the Rheumatologist’s Line of Sight |
| title_short |
IL-17 in the Rheumatologist’s Line of Sight |
| title_full |
IL-17 in the Rheumatologist’s Line of Sight |
| title_fullStr |
IL-17 in the Rheumatologist’s Line of Sight |
| title_full_unstemmed |
IL-17 in the Rheumatologist’s Line of Sight |
| title_sort |
il-17 in the rheumatologist’s line of sight |
| publisher |
Hindawi Limited |
| series |
BioMed Research International |
| issn |
2314-6133 2314-6141 |
| publishDate |
2013-01-01 |
| description |
Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis. Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed. |
| url |
http://dx.doi.org/10.1155/2013/295132 |
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AT marieelisetruchetet il17intherheumatologistslineofsight AT mdjavadmossalayi il17intherheumatologistslineofsight AT katiaboniface il17intherheumatologistslineofsight |
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