Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury

Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury

This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplantation (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Patients whose recovery had plateaued for longer than 6 months were enrolled. Six thoracic patients were tes...

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Main Authors: Jun Wu, Tiansheng Sun, Chaoqun Ye, Jianhua Yao, Bing Zhu, Hongying He
Format: Article
Language:English
Published: SAGE Publishing 2012-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X633743
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spelling doaj-cb1ff8a0135146dead0415a7530cc62f2020-11-25T03:07:36ZengSAGE PublishingCell Transplantation0963-68971555-38922012-01-012110.3727/096368912X633743Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord InjuryJun Wu0Tiansheng Sun1Chaoqun Ye2Jianhua Yao3Bing Zhu4Hongying He5Department of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaDepartment of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaDepartment of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaDepartment of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaDepartment of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaDepartment of Orthopedics, The Beijing Army General Hospital, Beijing, P.R. ChinaThis study was designed to observe the functional changes after fetal olfactory ensheathing glia transplantation (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Patients whose recovery had plateaued for longer than 6 months were enrolled. Six thoracic patients were tested for safety and five cervical patients for efficacy. OEGT was performed according to the method developed by Huang. Average follow-up was 14 months (range 1.0–1.5 years). Sensation improved moderately (light touch 14.2, pin prick 13.6); as did spasticity (1–2 modified Ashworth scale down). Locomotion recovery was minimal (1.6). Useful reticular formation functions were observed, but due to a lack of appropriate outcome measure, they were not recorded and reported.https://doi.org/10.3727/096368912X633743
collection DOAJ
language English
format Article
sources DOAJ
author Jun Wu
Tiansheng Sun
Chaoqun Ye
Jianhua Yao
Bing Zhu
Hongying He
spellingShingle Jun Wu
Tiansheng Sun
Chaoqun Ye
Jianhua Yao
Bing Zhu
Hongying He
Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
Cell Transplantation
author_facet Jun Wu
Tiansheng Sun
Chaoqun Ye
Jianhua Yao
Bing Zhu
Hongying He
author_sort Jun Wu
title Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
title_short Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
title_full Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
title_fullStr Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
title_full_unstemmed Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury
title_sort clinical observation of fetal olfactory ensheathing glia transplantation (oegt) in patients with complete chronic spinal cord injury
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2012-01-01
description This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplantation (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Patients whose recovery had plateaued for longer than 6 months were enrolled. Six thoracic patients were tested for safety and five cervical patients for efficacy. OEGT was performed according to the method developed by Huang. Average follow-up was 14 months (range 1.0–1.5 years). Sensation improved moderately (light touch 14.2, pin prick 13.6); as did spasticity (1–2 modified Ashworth scale down). Locomotion recovery was minimal (1.6). Useful reticular formation functions were observed, but due to a lack of appropriate outcome measure, they were not recorded and reported.
url https://doi.org/10.3727/096368912X633743
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