The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and...

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Bibliographic Details
Main Authors: Tongxin Ge, Jiawen Yang, Shihui Zhou, Yuchen Wang, Yakui Li, Xuemei Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Endocrinology
Subjects:
the pentose phosphate pathway
metabolism
obesity
diabetes
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00365/full

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