Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development

Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or suppress tumor progression. Inflammatory cytokines...

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Main Authors: Hsiang-Wei Huang, Cheng-Chih Chang, Chia-Siu Wang, Kwang-Huei Lin
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/10/1/67
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spelling doaj-cb0977eec5cc42b8b933cd8b7faba1432021-01-05T00:02:57ZengMDPI AGCells2073-44092021-01-0110676710.3390/cells10010067Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer DevelopmentHsiang-Wei Huang0Cheng-Chih Chang1Chia-Siu Wang2Kwang-Huei Lin3Department of Biochemistry, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of General Surgery, Chang Gung Memorial Hospital at Chia-yi, Chia-yi 613, TaiwanDepartment of General Surgery, Chang Gung Memorial Hospital at Chia-yi, Chia-yi 613, TaiwanDepartment of Biochemistry, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or suppress tumor progression. Inflammatory cytokines within the tumor microenvironment promote immune cell infiltration. Infiltrating immune, and tumor-surrounding stromal cells support tumor growth, angiogenesis, metastasis, and immunosuppression through communication with inflammatory cytokines and cell adhesion molecules. Notably, infiltrating immune and tumor cells present immunosuppressive molecules, such as programmed death-ligand 1 (PD-L1) and CD80/CD86. Suppression of cytotoxic T cells promotes tumor avoidance of immune surveillance and greater malignancy. Moreover, glycosylation and sialylation of proteins hyperexpressed on the cancer cell surface have been shown to enhance immune escape and metastasis. Cytokine treatments and immune checkpoint inhibitors are widely used in clinical practice. However, the tumor microenvironment is a rapidly changing milieu involving several factors. In this review, we have provided a summary of the interactions of inflammation and cell adhesion molecules between cancer and other cell types, to improve understanding of the tumor microenvironment.https://www.mdpi.com/2073-4409/10/1/67gastrointestinal cancerinflammationtumor microenvironmentcell adhesion molecule
collection DOAJ
language English
format Article
sources DOAJ
author Hsiang-Wei Huang
Cheng-Chih Chang
Chia-Siu Wang
Kwang-Huei Lin
spellingShingle Hsiang-Wei Huang
Cheng-Chih Chang
Chia-Siu Wang
Kwang-Huei Lin
Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
Cells
gastrointestinal cancer
inflammation
tumor microenvironment
cell adhesion molecule
author_facet Hsiang-Wei Huang
Cheng-Chih Chang
Chia-Siu Wang
Kwang-Huei Lin
author_sort Hsiang-Wei Huang
title Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
title_short Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
title_full Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
title_fullStr Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
title_full_unstemmed Association between Inflammation and Function of Cell Adhesion Molecules Influence on Gastrointestinal Cancer Development
title_sort association between inflammation and function of cell adhesion molecules influence on gastrointestinal cancer development
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-01-01
description Gastrointestinal cancer is highly associated with inflammatory processes inducing the release of cytokines from cancer or immune cells, including interferons, interleukins, chemokines, colony-stimulating factors, and growth factors, which promote or suppress tumor progression. Inflammatory cytokines within the tumor microenvironment promote immune cell infiltration. Infiltrating immune, and tumor-surrounding stromal cells support tumor growth, angiogenesis, metastasis, and immunosuppression through communication with inflammatory cytokines and cell adhesion molecules. Notably, infiltrating immune and tumor cells present immunosuppressive molecules, such as programmed death-ligand 1 (PD-L1) and CD80/CD86. Suppression of cytotoxic T cells promotes tumor avoidance of immune surveillance and greater malignancy. Moreover, glycosylation and sialylation of proteins hyperexpressed on the cancer cell surface have been shown to enhance immune escape and metastasis. Cytokine treatments and immune checkpoint inhibitors are widely used in clinical practice. However, the tumor microenvironment is a rapidly changing milieu involving several factors. In this review, we have provided a summary of the interactions of inflammation and cell adhesion molecules between cancer and other cell types, to improve understanding of the tumor microenvironment.
topic gastrointestinal cancer
inflammation
tumor microenvironment
cell adhesion molecule
url https://www.mdpi.com/2073-4409/10/1/67
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