Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study

Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study

IntroductionThe emergence of psychosis in at-risk individuals results from interactions between genetic vulnerability and environmental factors, possibly involving dysregulation of the hypothalamic-pituitary-adrenal axis. Hypercorticism was indeed described in schizophrenia and ultra-high-risk state...

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Main Authors: Anton Iftimovici, Oussama Kebir, Qin He, Thérèse M. Jay, ICAAR Study Group, Guy A. Rouleau, Marie-Odile Krebs, Boris Chaumette, Isabelle Amado, Julie Bourgin, Claire Daban Huard, Célia Jantac Mam-Lam-Fook, Marion Plaze, Fabrice Rivollier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Psychiatry
Subjects:
ultra-high risk of psychosis
stress
cortisol
hypothalamic–pituitary–adrenal axis
Mendelian randomization
expression quantitative trait locus
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00680/full

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