Development and Application of High-Content Biological Screening for Modulators of NET Production

Development and Application of High-Content Biological Screening for Modulators of NET Production

Neutrophil extracellular traps (NETs) are DNA-based antimicrobial web-like structures whose release is predominantly mediated by reactive oxygen species (ROS); their purpose is to combat infections. However, unbalanced NET production and clearance is involved in tissue injury, circulation of auto-an...

Full description

Bibliographic Details
Main Authors: Ilaria J. Chicca, Michael R. Milward, Iain Leslie C. Chapple, Gareth Griffiths, Rod Benson, Thomas Dietrich, Paul R. Cooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
neutrophil extracellular traps
high-content analysis
high-content screening
nuclear decondensation
MAPK
Src
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00337/full

Similar Items

Similar Items