Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacolog...

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Main Authors:	Gabriella R Sterne, Jung Hwan Kim, Bing Ye
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-05-01
Series:	eLife
Subjects:	Dscam Abl fragile X syndrome tyrosine kinase inhibitor presynaptic terminal neuronal development
Online Access:	https://elifesciences.org/articles/05196

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record_format	Article
spelling	doaj-caf56b3cac0d4b5db9108de267d8e41a2021-05-04T23:48:55ZengeLife Sciences Publications LtdeLife2050-084X2015-05-01410.7554/eLife.05196Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arborsGabriella R Sterne0Jung Hwan Kim1Bing Ye2Life Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesLife Sciences Institute, University of Michigan, Ann Arbor, United States; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, United StatesIncreased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression.https://elifesciences.org/articles/05196DscamAblfragile X syndrometyrosine kinase inhibitorpresynaptic terminalneuronal development
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gabriella R Sterne Jung Hwan Kim Bing Ye
spellingShingle	Gabriella R Sterne Jung Hwan Kim Bing Ye Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors eLife Dscam Abl fragile X syndrome tyrosine kinase inhibitor presynaptic terminal neuronal development
author_facet	Gabriella R Sterne Jung Hwan Kim Bing Ye
author_sort	Gabriella R Sterne
title	Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
title_short	Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
title_full	Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
title_fullStr	Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
title_full_unstemmed	Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors
title_sort	dysregulated dscam levels act through abelson tyrosine kinase to enlarge presynaptic arbors
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2015-05-01
description	Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression.
topic	Dscam Abl fragile X syndrome tyrosine kinase inhibitor presynaptic terminal neuronal development
url	https://elifesciences.org/articles/05196
work_keys_str_mv	AT gabriellarsterne dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors AT junghwankim dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors AT bingye dysregulateddscamlevelsactthroughabelsontyrosinekinasetoenlargepresynapticarbors
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Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

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