Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors

Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacolog...

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Bibliographic Details
Main Authors: Gabriella R Sterne, Jung Hwan Kim, Bing Ye
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
Dscam
Abl
fragile X syndrome
tyrosine kinase inhibitor
presynaptic terminal
neuronal development
Online Access:https://elifesciences.org/articles/05196
Description
Summary:Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression.
ISSN:2050-084X

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