Phenotypic Characteristics and the Susceptibility of Haemophilus influenzae to the Antimicrobial Agents in Russia (2004 - 2016)

• Main Authors: M. A. Koroleva, I. S. Koroleva, I. M. Gruber, L. S. Cherkasova
• Format: Article
• Language: Russian
• Published: Numikom LLC 2017-04-01
• Series: Эпидемиология и вакцинопрофилактика
• Subjects: гемофильная инфекция; гемофильная палочка; менингит; резистентность к антибактериальным препаратам; haemophilus influenzae; meningitis; antimicrobial resistance
• Online Access: https://www.epidemvac.ru/jour/article/view/253
• ISSN: 2073-3046; 2619-0494

The aim. The study of phenotypic characteristics and dynamics of sensitivity to antibiotics Russian invasive strains H. influenzae. Materials and methods. Studied 89 Russian invasive strains H. influenzae for the period 13-year period (2004 - 2016). To study metabolic, enzymatic activity and beta-lactamase and biotype characteristics H. influenzae strains. Studied H. influenzae sensitivity to antibiotics. Results. Most strains related H. influenzae serotype b (86,1%), biotype II (69,7%), VII (16,9%), I (13,5%). Ampicillin-resistant strains accounted for 10.1%. All of them produced the enzyme beta-lactamase. Conclusion. The population of the Russian invasive ampicillin-resistant H. influenzae strains accounted for 10.1%. The mechanism of resistance to ampicillin is the production of the enzyme beta-lactamase.