THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE

THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE

In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond this gene...

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Main Authors: Valérie Urbach, Gerard Higgins, Paul Buchanan, Fiona Ringholz
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Computational and Structural Biotechnology Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014601276
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spelling doaj-caf0734f4a3e44feb70a20fb8b2fd9232020-11-24T22:18:49ZengElsevierComputational and Structural Biotechnology Journal2001-03702013-03-016710.5936/csbj.201303018THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASEValérie Urbach0Gerard Higgins1Paul Buchanan2Fiona Ringholz3National Children's Research Centre, Crumlin, Dublin 12, IrelandNational Children's Research Centre, Crumlin, Dublin 12, IrelandNational Children's Research Centre, Crumlin, Dublin 12, IrelandNational Children's Research Centre, Crumlin, Dublin 12, IrelandIn Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond this general description, the pathogenesis of CF lung disease remains obscure due to an incomplete understanding of normal innate airway defense. This mini-review aims to highlight the role of the pro-resolution lipid mediator, Lipoxin A4, which is inadequately produced in CF, on several aspects of innate immunity that are altered in CF airway disease.http://www.sciencedirect.com/science/article/pii/S2001037014601276
collection DOAJ
language English
format Article
sources DOAJ
author Valérie Urbach
Gerard Higgins
Paul Buchanan
Fiona Ringholz
spellingShingle Valérie Urbach
Gerard Higgins
Paul Buchanan
Fiona Ringholz
THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
Computational and Structural Biotechnology Journal
author_facet Valérie Urbach
Gerard Higgins
Paul Buchanan
Fiona Ringholz
author_sort Valérie Urbach
title THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
title_short THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
title_full THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
title_fullStr THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
title_full_unstemmed THE ROLE OF LIPOXIN A4 IN CYSTIC FIBROSIS LUNG DISEASE
title_sort role of lipoxin a4 in cystic fibrosis lung disease
publisher Elsevier
series Computational and Structural Biotechnology Journal
issn 2001-0370
publishDate 2013-03-01
description In Cystic Fibrosis (CF), mutations of the CFTR gene result in defective Cl− secretion and Na+ hyperabsorption by epithelia which leads to airway lumen dehydration and mucus plugging and favours chronic bacterial colonization, persistent inflammation and progressive lung destruction. Beyond this general description, the pathogenesis of CF lung disease remains obscure due to an incomplete understanding of normal innate airway defense. This mini-review aims to highlight the role of the pro-resolution lipid mediator, Lipoxin A4, which is inadequately produced in CF, on several aspects of innate immunity that are altered in CF airway disease.
url http://www.sciencedirect.com/science/article/pii/S2001037014601276
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