Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site

Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site

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<p>Abstract</p> <p>Development of antimitotic binding to the colchicine-binding site for the treatment of cancer is rapidly expanding. Numerous antimicrotubule agents are prepared every year, and the determination of their binding affinity to tubulin requires the use of purified tu...

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Bibliographic Details
Main Authors: Fortin Sébastien, Lacroix Jacques, Côté Marie-France, Moreau Emmanuel, Petitclerc Éric, C-Gaudreault René
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Biological Procedures Online
Subjects:
colchicine-binding site inhibitor
taxol-binding site inhibitor
<it>N</it>,<it>N</it>'-ethylene-bis(iodoacetamide)
EBI
tubulin affinity assay
antimicrotubule agent
Online Access:http://www.biologicalproceduresonline.com/content/12/1/9029

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