FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS

We investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblas...

Full description

Bibliographic Details
Main Authors:	S. A. Trulioff, I. V. Kudryavtsev, P. G. Nazarov
Format:	Article
Language:	Russian
Published:	Scientific Сentre for Family Health and Human Reproduction Problems 2012-05-01
Series:	Acta Biomedica Scientifica
Subjects:	anaphylatoxins c-reactive protein mast cells fibroblasts
Online Access:	https://www.actabiomedica.ru/jour/article/view/944

id	doaj-cadca21efc72468a9a47f82b921dd2d0
record_format	Article
spelling	doaj-cadca21efc72468a9a47f82b921dd2d02021-08-17T13:52:39ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)319322890FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTSS. A. Trulioff0I. V. Kudryavtsev1P. G. Nazarov2Institute of Experimental Medicine, North-West Branch RAMSInstitute of Experimental Medicine, North-West Branch RAMSInstitute of Experimental Medicine, North-West Branch RAMSWe investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblasts (FB). HMC-1 MC line and primary human foreskin FB were used. MC or FB were treated with each of the studied inflammatory proteins within 24 h and then the changes in their adhesive properties were examined. Cell adhesion was assessed by flow cytometry. The results showed that all studied proteins increased MC adhesiveness, whereas FB adhesiveness was increased only by anaphylatoxins. Stimulation of the adhesive properties of the MC was associated with increased expression of CD11b and ICAM-1 molecules.https://www.actabiomedica.ru/jour/article/view/944anaphylatoxinsc-reactive proteinmast cellsfibroblasts
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov
spellingShingle	S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS Acta Biomedica Scientifica anaphylatoxins c-reactive protein mast cells fibroblasts
author_facet	S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov
author_sort	S. A. Trulioff
title	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_short	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_full	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_fullStr	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_full_unstemmed	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_sort	factors of the acute phase of inflammation as modulators of the interaction of mast cells and fibroblasts
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
series	Acta Biomedica Scientifica
issn	2541-9420 2587-9596
publishDate	2012-05-01
description	We investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblasts (FB). HMC-1 MC line and primary human foreskin FB were used. MC or FB were treated with each of the studied inflammatory proteins within 24 h and then the changes in their adhesive properties were examined. Cell adhesion was assessed by flow cytometry. The results showed that all studied proteins increased MC adhesiveness, whereas FB adhesiveness was increased only by anaphylatoxins. Stimulation of the adhesive properties of the MC was associated with increased expression of CD11b and ICAM-1 molecules.
topic	anaphylatoxins c-reactive protein mast cells fibroblasts
url	https://www.actabiomedica.ru/jour/article/view/944
work_keys_str_mv	AT satrulioff factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts AT ivkudryavtsev factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts AT pgnazarov factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts
_version_	1721205035146149888

FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS

Similar Items