Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues

Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues

Paracetamol/acetaminophen (APAP) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic agent. The metabolism of this drug occurs in the liver and leads to the formation of two main metabolites—glucuronic acid and sulfate derivate. Despite the wide use of...

Full description

Bibliographic Details
Main Authors: Konrad Pietruk, Małgorzata Gbylik-Sikorska, Beata Łebkowska-Wieruszewska, Anna Gajda, Mario Giorgi, Irene Sartini, Piotr Jedziniak
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
paracetamol
metabolites
muscle
heart
lungs
liver
Online Access:https://www.mdpi.com/1420-3049/26/7/2046

Internet

https://www.mdpi.com/1420-3049/26/7/2046

Similar Items