An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice

An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice

Oral route colon-targeted drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC). However, CDDSs are challenging owing to the physiological and anatomical barriers associated with the gastrointestinal tract (GIT). In this study, we developed an effective enzyme-trig...

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Bibliographic Details
Main Authors: Shangyong Li, Mengfei Jin, Yanhong Wu, Samil Jung, Dandan Li, Ningning He, Myeong-sok Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
colon-targeted drug delivery
enzyme-triggered controlled release
ulcerative colitis
intestinal homeostasis
gut microbiota
Online Access:http://dx.doi.org/10.1080/10717544.2021.1934189

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