Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB

Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB

Calycosin, an isoflavonoid phytoestrogen, isolated from Radix Astragali, was reported to possess anti-tumor, anti-inflammation, and osteogenic properties, but its impact on osteoclast differentiation remains unclear. In this study, we examined the effects of calycosin on osteoclastogenesis induced b...

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Bibliographic Details
Main Authors:	Gui-Hua Quan, Hongbing Wang, Jinjin Cao, Yuxin Zhang, Donglin Wu, Qisheng Peng, Ning Liu, Wan-Chun Sun
Format:	Article
Language:	English
Published:	MDPI AG 2015-12-01
Series:	International Journal of Molecular Sciences
Subjects:	calycosin osteoclast bone resorption NFATc1 c-Fos NF-κB MAPKs
Online Access:	http://www.mdpi.com/1422-0067/16/12/26179

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