CORRELATION BETWEEN INFLAMMATORY PARAMETERS AND MARKERS OF CHOLESTASIS IN PATIENTS WITH CHOLEDOCHOLITHIASIS

• Main Authors: Zoran Damnjanović, Milan Jovanović, Aleksandar Nagorni, Dušan Sokolović, Boris Đinđić, Goran Damnjanović, Nemanja Stepanović, Marija Trenkić Božinović
• Format: Article
• Language: English
• Published: University in Nis, Faculty of Medicine 2014-06-01
• Series: Acta Medica Medianae
• Subjects: cholestasis; inflammation; choledocholithiasis
• Online Access: http://publisher.medfak.ni.ac.rs/2014-html/2-broj/Zoran%20Damnjanovic-Correlation.pdf
• ISSN: 0365-4478; 1821-2794

The aim of this research was to examine the relationship between inflammatory parameters and markers of cholestasis in patients with choledocholithiasis. All subjects underwent clinical, laboratory and ultrasound examination at the Department of Internal Medicine, Military Hospital Niš, Serbia. Inflammatory parameters and biochemical markers of cholestasis were measured by standard biochemical methods. Most of cholestasis markers showed no significant correlation with inflammatory parameters in blood, except for a weak significant correlation between the number of monocytes with the activity of aspartate aminotransferase (AST) (r=0.37, p<0.05). Hyperbilirubinemia was significantly correlated with the fibrinogen values (r=0.42, p<0.05), while albumin positive values were positively associated with alanine aminotransferase (ALT) activity (r=0.5, p<0.05), and negatively with the alkaline phosphatase (AP) (r=-0.43, p<0.05). In patients with choledocholithiasis, there was a positive correlation between the number of monocytes and the activities of AST, hyperbilirubinemia, and fibrinogen, albumin and ALT, while a negative correlation between albumin and AP was present.