Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles

Recent Advances in Cryo-TEM Imaging of Soft Lipid Nanoparticles

Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fix...

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Bibliographic Details
Main Authors: Shen Helvig, Intan D. M. Azmi, Seyed M. Moghimi, Anan Yaghmur
Format: Article
Language:English
Published: AIMS Press 2015-05-01
Series:AIMS Biophysics
Subjects:
cryo-TEM
cubosomes
3D tomography
hexosomes
nanocarriers
Online Access:http://www.aimspress.com/biophysics/article/283/fulltext.html
Description
Summary:Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.
ISSN:2377-9098

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