Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue d...

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Main Authors: Mahajan Manojkumar S., Upaganlawar Aman B., Upasani Chandrashekar D.
Format: Article
Language:English
Published: Sciendo 2021-06-01
Series:European Pharmaceutical Journal
Subjects:
diabetic nephropathy
oxidative stress
streptozotocin
coenzyme q10
n-acetylcysteine
Online Access:https://doi.org/10.2478/afpuc-2020-0020
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spelling doaj-cab3b820a24e460fbc19dccfba845d112021-10-03T07:42:44ZengSciendoEuropean Pharmaceutical Journal2453-67252021-06-01681303910.2478/afpuc-2020-0020Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic NephropathyMahajan Manojkumar S.0Upaganlawar Aman B.1Upasani Chandrashekar D.2Shri Neminath Jain Brahmacharyashram Trust's, Shreeman Sureshdada Jain College of Pharmacy, Nashik, Maharashtra, IndiaShri Neminath Jain Brahmacharyashram Trust's, Shreeman Sureshdada Jain College of Pharmacy, Nashik, Maharashtra, IndiaShri Neminath Jain Brahmacharyashram Trust's, Shreeman Sureshdada Jain College of Pharmacy, Nashik, Maharashtra, IndiaOxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue damage to improve renal physiology during DN. The investigation, therefore, was designed to assess the nephroprotective effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), either alone or in combination in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic nephropathy (DN) in rats.https://doi.org/10.2478/afpuc-2020-0020diabetic nephropathyoxidative stressstreptozotocincoenzyme q10n-acetylcysteine
collection DOAJ
language English
format Article
sources DOAJ
author Mahajan Manojkumar S.
Upaganlawar Aman B.
Upasani Chandrashekar D.
spellingShingle Mahajan Manojkumar S.
Upaganlawar Aman B.
Upasani Chandrashekar D.
Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
European Pharmaceutical Journal
diabetic nephropathy
oxidative stress
streptozotocin
coenzyme q10
n-acetylcysteine
author_facet Mahajan Manojkumar S.
Upaganlawar Aman B.
Upasani Chandrashekar D.
author_sort Mahajan Manojkumar S.
title Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_short Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_full Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_fullStr Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_full_unstemmed Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_sort nephroprotective effect of coenzyme q10 alone and in combination with n-acetylcysteine in diabetic nephropathy
publisher Sciendo
series European Pharmaceutical Journal
issn 2453-6725
publishDate 2021-06-01
description Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue damage to improve renal physiology during DN. The investigation, therefore, was designed to assess the nephroprotective effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), either alone or in combination in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic nephropathy (DN) in rats.
topic diabetic nephropathy
oxidative stress
streptozotocin
coenzyme q10
n-acetylcysteine
url https://doi.org/10.2478/afpuc-2020-0020
work_keys_str_mv AT mahajanmanojkumars nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy
AT upaganlawaramanb nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy
AT upasanichandrashekard nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy
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