RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation

Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma (PTC). We have previously shown that, in human primary thyrocytes, RET/PTC1 induces a transcriptional program including the MET proto-oncoge...

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Bibliographic Details
Main Authors: Giuliana Cassinelli, Enrica Favini, Debora Degl'Innocenti, Alessandro Salvi, Giuseppina De Petro, Marco A. Pierotti, Franco Zunino, Maria Grazia Borrello, Cinzia Lanzi
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609800845

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http://www.sciencedirect.com/science/article/pii/S1476558609800845

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