The dinucleotide composition of the Zika virus genome is shaped by conflicting evolutionary pressures in mammalian hosts and mosquito vectors.

The dinucleotide composition of the Zika virus genome is shaped by conflicting evolutionary pressures in mammalian hosts and mosquito vectors.

Most vertebrate RNA viruses show pervasive suppression of CpG and UpA dinucleotides, closely resembling the dinucleotide composition of host cell transcriptomes. In contrast, CpG suppression is absent in both invertebrate mRNA and RNA viruses that exclusively infect arthropods. Arthropod-borne (arbo...

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Main Authors: Jelke J Fros, Imke Visser, Bing Tang, Kexin Yan, Eri Nakayama, Tessa M Visser, Constantianus J M Koenraadt, Monique M van Oers, Gorben P Pijlman, Andreas Suhrbier, Peter Simmonds
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001201

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https://doi.org/10.1371/journal.pbio.3001201

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