Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota

Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota

This work investigated the effects of fermented ginseng leaf (FGL) consumption on metabolites of muscular interstitial fluid, satellite cell-mediated muscle cell repair and gut microbiota in exercise-induced fatigue rats. First nano Fe3O4@glucose oxidase-assisted fermentation significantly increased...

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Main Authors: Ziyi Zheng, Guo Xie, Hongxia Liu, Guiliang Tan, Lin Li, Wenli Liu, Mei Li
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Journal of Functional Foods
Subjects:
Ginseng leaf
Muscular interstitial fluid
Gut microbiota
Exercise-induced fatigue
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621001584
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spelling doaj-caa5694fabe8493c847fbfea591143782021-06-19T04:53:20ZengElsevierJournal of Functional Foods1756-46462021-08-0183104509Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiotaZiyi Zheng0Guo Xie1Hongxia Liu2Guiliang Tan3Lin Li4Wenli Liu5Mei Li6School of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaCorresponding author.; School of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaSchool of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaSchool of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaSchool of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaSchool of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaSchool of Material Science and Food Engineering, University of Electronic Science and Technology of China, Zhongshan Institute, 1 Xueyuan Road, Zhongshan 528402, Guangdong Province, People’s Republic of ChinaThis work investigated the effects of fermented ginseng leaf (FGL) consumption on metabolites of muscular interstitial fluid, satellite cell-mediated muscle cell repair and gut microbiota in exercise-induced fatigue rats. First nano Fe3O4@glucose oxidase-assisted fermentation significantly increased the ginsenosides contents of Rh2 and Rg3. Furthermore, the levels of hypoxanthine and isoprostane significantly increased in fatigue rats compared with the control. Meanwhile, remarkable decline of bacterial diversity, abundances of Bacteroidaceae, Allobaculum and Akkermansia were found. However, FGL consumption ameliorated these biomarkers. Exhaustive Exercise significantly elevated the protein expression of MyHC-I and MyHC-II, and decreased fiber cross sectional areas. FGL significantly increased protein expression of Pax7 and MyoD1, and decreased gene expression of MyHC-I and MyHC-IIb. The levels of acetic acid, propionic acid, total short chain fatty acids, TNF-α and IL-10 significantly altered in fatigue rats, whilst FGL significantly ameliorate them. These findings suggested potential benefits of FGL for alleviating exercise-induced fatigue.http://www.sciencedirect.com/science/article/pii/S1756464621001584Ginseng leafMuscular interstitial fluidGut microbiotaExercise-induced fatigue
collection DOAJ
language English
format Article
sources DOAJ
author Ziyi Zheng
Guo Xie
Hongxia Liu
Guiliang Tan
Lin Li
Wenli Liu
Mei Li
spellingShingle Ziyi Zheng
Guo Xie
Hongxia Liu
Guiliang Tan
Lin Li
Wenli Liu
Mei Li
Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
Journal of Functional Foods
Ginseng leaf
Muscular interstitial fluid
Gut microbiota
Exercise-induced fatigue
author_facet Ziyi Zheng
Guo Xie
Hongxia Liu
Guiliang Tan
Lin Li
Wenli Liu
Mei Li
author_sort Ziyi Zheng
title Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
title_short Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
title_full Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
title_fullStr Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
title_full_unstemmed Fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
title_sort fermented ginseng leaf enriched with rare ginsenosides relieves exercise-induced fatigue via regulating metabolites of muscular interstitial fluid, satellite cells-mediated muscle repair and gut microbiota
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2021-08-01
description This work investigated the effects of fermented ginseng leaf (FGL) consumption on metabolites of muscular interstitial fluid, satellite cell-mediated muscle cell repair and gut microbiota in exercise-induced fatigue rats. First nano Fe3O4@glucose oxidase-assisted fermentation significantly increased the ginsenosides contents of Rh2 and Rg3. Furthermore, the levels of hypoxanthine and isoprostane significantly increased in fatigue rats compared with the control. Meanwhile, remarkable decline of bacterial diversity, abundances of Bacteroidaceae, Allobaculum and Akkermansia were found. However, FGL consumption ameliorated these biomarkers. Exhaustive Exercise significantly elevated the protein expression of MyHC-I and MyHC-II, and decreased fiber cross sectional areas. FGL significantly increased protein expression of Pax7 and MyoD1, and decreased gene expression of MyHC-I and MyHC-IIb. The levels of acetic acid, propionic acid, total short chain fatty acids, TNF-α and IL-10 significantly altered in fatigue rats, whilst FGL significantly ameliorate them. These findings suggested potential benefits of FGL for alleviating exercise-induced fatigue.
topic Ginseng leaf
Muscular interstitial fluid
Gut microbiota
Exercise-induced fatigue
url http://www.sciencedirect.com/science/article/pii/S1756464621001584
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