Astrocyte Elevated Gene-1 Increases Invasiveness of NSCLC Through Up-Regulating MMP7

Astrocyte Elevated Gene-1 Increases Invasiveness of NSCLC Through Up-Regulating MMP7

Background/Aims: The aggressive manner of non-small cell lung cancer (NSCLC) cells accounts for the majority of the lethality of the disease. Recently, increased astrocyte elevated gene-1 (AEG-1) levels have been shown to closely correlate with poor prognosis of NSCLC, whereas the underlying mechani...

Full description

Bibliographic Details
Main Authors:	Ren Zhu, Ye Tian
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:	Cellular Physiology and Biochemistry
Subjects:	ERK/MAPK signaling pathway Non-small cell lung cancer (NSCLC) Astrocyte elevated gene-1 (AEG-1) Matrix metalloproteinase 7 (MMP7) Metastases
Online Access:	http://www.karger.com/Article/FullText/430242

Similar Items

Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration
by: Vartak-Sharma Neha, et al.
Published: (2012-08-01)

Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway
by: Danni Wang, et al.
Published: (2016-11-01)

AEG-1 Regulates TWIK-1 Expression as an RNA-Binding Protein in Astrocytes
by: Hyun-Gug Jung, et al.
Published: (2021-01-01)

CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9
by: Weiling He, et al.
Published: (2018-04-01)

MMP-7 and fcDNA Serum Levels in Early NSCLC and Idiopathic Interstitial Pneumonia: Preliminary Study
by: Paola Ulivi, et al.
Published: (2013-12-01)

Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
by: Dan Li, et al.
Published: (2017-03-01)

Plasma Concentrations of Matrilysins MMP-7 and MMP-26 as Diagnostic Biomarkers in Breast Cancer
by: Barbara Maria Piskór, et al.
Published: (2021-04-01)

Bi-directional immuno-modulation by Matrix Metalloproteinase-7 (MMP-7) and A Disintegrin And Metalloproteinase-17 (ADAM-17) as transplantation rejection-tolerance spectrum
by: Robert Chen
Published: (2016-05-01)

High expression level of MMP9 is associated with poor prognosis in patients with clear cell renal carcinoma
by: Haitao Niu, et al.
Published: (2018-07-01)

The Scope of Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH) in Cancer Clinicopathology: A Review
by: Maheen Khan, et al.
Published: (2021-02-01)

MMP-7 is Required for TGF-β and EGF Induced Migration and Invasion in Prostate Cancer Cells
by: Bolton, Clement, II
Published: (2018)

Serum levels of MMP-7 in primary brain cancers and brain metastases
by: Ivelina Dimitrova, et al.
Published: (2019-01-01)

The Expression Level and Clinical Significance of MMP-7 Protein  in Peripheral Blood in the Patients with Lung Cancer
by: Xiaoliang SUN, et al.
Published: (2012-12-01)

AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma
by: Jiaqin Yan, et al.
Published: (2018-07-01)

Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma
by: Liao Wen-Ting, et al.
Published: (2011-12-01)

Biphasic Regulation of Caveolin-1 Gene Expression by Fluoxetine in Astrocytes: Opposite Effects of PI3K/AKT and MAPK/ERK Signaling Pathways on c-fos
by: Baoman Li, et al.
Published: (2017-10-01)

Placental Growth Factor Promotes Metastases of Non-Small Cell Lung Cancer Through MMP9
by: Wei Zhang, et al.
Published: (2015-09-01)

Aldehyde Dehydrogenase 1 (ALDH1) Promotes the Toxicity of TRAIL in Non-Small Cell Lung Cancer Cells via Post-Transcriptional Regulation of MEK-1 Expression
by: Shuang Tian, et al.
Published: (2018-11-01)

Chemokine Receptor 7 Induces Metastasis of NSCLC via Upregulating MMP-9 Expression
by: Yang LI, et al.
Published: (2010-11-01)

Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo
by: Emma Muñoz-Sáez, et al.
Published: (2021-09-01)

Association of the MMP7 –181A>G promoter polymorphism with early onset of chronic obstructive pulmonary disease
by: Tacheva T, et al.
Published: (2017-12-01)

Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review
by: Sushmitha Sriramulu, et al.
Published: (2021-06-01)

SDF-1 and MMP2 cross talk in cancer cells and tumor microenvironment in non-small cell lung
by: Nehad M. Osman, et al.
Published: (2016-04-01)

<i>MMP2</i> Polymorphism Affects Plasma Matrix Metalloproteinase (MMP)-2 Levels, and Correlates with the Decline in Lung Function in Hypersensitivity Pneumonitis Positive to Autoantibodies Patients
by: Luis Santiago-Ruiz, et al.
Published: (2019-10-01)

Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
by: Sonia Pahwa, et al.
Published: (2014-02-01)

Levels of Selected Matrix Metalloproteinases—MMP-1, MMP-2 and Fibronectin in the Saliva of Patients Planned for Endodontic Treatment or Surgical Extraction
by: Ewa Matuszczak, et al.
Published: (2020-12-01)

The role of MMP-2 and MMP-9 in the metastasis and development of hypopharyngeal carcinoma
by: Zhe Song, et al.
Published: (2021-09-01)

2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways
by: Shenghong Wang, et al.
Published: (2018-08-01)

SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation
by: Yuyan Gao, et al.
Published: (2019-07-01)

Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance
by: Debashri Manna, et al.
Published: (2021-04-01)

Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke
by: Fang-I Hsieh, et al.
Published: (2019-11-01)

Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses
by: Huyue Zhou, et al.
Published: (2020-07-01)

EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes
by: Hong, Z., et al.
Published: (2022)

MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
by: Shixing Ma, et al.
Published: (2020-05-01)

Placental Growth Factor Promotes Metastases of Ovarian Cancer Through MiR-543-Regulated MMP7
by: Ning Song, et al.
Published: (2015-09-01)

MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction
by: Carla Loreto, et al.
Published: (2020-04-01)

Soluble Syndecan-1 Levels Are Associated with Survival in Platinum-Treated Bladder Cancer Patients
by: Csilla Olah, et al.
Published: (2020-10-01)

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes
by: Hyunju Park, et al.
Published: (2017-12-01)

MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells
by: J. Zhang, et al.
Published: (2014-02-01)

DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway
by: Jie Niu, et al.
Published: (2019-06-01)