Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome

Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome

The aim of this study was to investigate the relationship between pentraxin-3 and other biochemical parameters in women with polycystic ovary syndrome (PCOS). We compared 58 women with PCOS to 34 body mass index- and age-matched normally menstruating healthy controls. Women with PCOS had significant...

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Main Authors: N. Güdücü, U. Görmüş, E. Alp, Z.N. Kavak, İ. Dünder
Format: Article
Language:English
Published: SAGE Publishing 2014-01-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X1401200115
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spelling doaj-ca8f3058078841488a66c448878ddb772020-11-25T03:15:28ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2014-01-011210.1177/1721727X1401200115Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary SyndromeN. Güdücü0U. Görmüş1E. Alp2Z.N. Kavak3İ. Dünder4 İstanbul Bilim University, Department of Obstetrics and Gynecology, Istanbul, Turkey İstanbul Bilim University, Department of Biochemistry, Istanbul, Turkey İstanbul Bilim University, Department of Biochemistry, Istanbul, Turkey Marmara University, Department of Obstetrics and Gynecology, Istanbul, Turkey İstanbul Bilim University, Department of Obstetrics and Gynecology, Istanbul, TurkeyThe aim of this study was to investigate the relationship between pentraxin-3 and other biochemical parameters in women with polycystic ovary syndrome (PCOS). We compared 58 women with PCOS to 34 body mass index- and age-matched normally menstruating healthy controls. Women with PCOS had significantly higher DHEA-S, free testosterone, LH and FAI, but lower pentraxin-3 levels when compared to healthy controls (0.86±0.21 and 0.91±0.14 respectively, p=0.014). Levels of CRP and lipoprotein-a were higher in the PCOS group. Overweight PCOS had significantly higher insulin, HOMA-IR, FAI, free testosterone and CRP and statistically significantly lower HDL and SHBG levels when compared to controls. Pentraxin-3 levels of obese and normal weight PCOS were similar. CRP and pentraxin-3 might contribute reciprocally to metabolic events and chronic low-grade inflammation in women with PCOS.https://doi.org/10.1177/1721727X1401200115
collection DOAJ
language English
format Article
sources DOAJ
author N. Güdücü
U. Görmüş
E. Alp
Z.N. Kavak
İ. Dünder
spellingShingle N. Güdücü
U. Görmüş
E. Alp
Z.N. Kavak
İ. Dünder
Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
European Journal of Inflammation
author_facet N. Güdücü
U. Görmüş
E. Alp
Z.N. Kavak
İ. Dünder
author_sort N. Güdücü
title Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
title_short Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
title_full Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
title_fullStr Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
title_full_unstemmed Reciprocal Action of Pentraxin-3 and CRP in Women with Polycystic Ovary Syndrome
title_sort reciprocal action of pentraxin-3 and crp in women with polycystic ovary syndrome
publisher SAGE Publishing
series European Journal of Inflammation
issn 1721-727X
publishDate 2014-01-01
description The aim of this study was to investigate the relationship between pentraxin-3 and other biochemical parameters in women with polycystic ovary syndrome (PCOS). We compared 58 women with PCOS to 34 body mass index- and age-matched normally menstruating healthy controls. Women with PCOS had significantly higher DHEA-S, free testosterone, LH and FAI, but lower pentraxin-3 levels when compared to healthy controls (0.86±0.21 and 0.91±0.14 respectively, p=0.014). Levels of CRP and lipoprotein-a were higher in the PCOS group. Overweight PCOS had significantly higher insulin, HOMA-IR, FAI, free testosterone and CRP and statistically significantly lower HDL and SHBG levels when compared to controls. Pentraxin-3 levels of obese and normal weight PCOS were similar. CRP and pentraxin-3 might contribute reciprocally to metabolic events and chronic low-grade inflammation in women with PCOS.
url https://doi.org/10.1177/1721727X1401200115
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