Strategies for Developing Sensitive and Automated LC-MS/MS Assays of a Pharmaceutical Compound and Its Metabolite from Whole Blood Matrix

Strategies for Developing Sensitive and Automated LC-MS/MS Assays of a Pharmaceutical Compound and Its Metabolite from Whole Blood Matrix

When compared with biological samples in other matrices (plasma, urine, etc.) that are typically seen in bioanalytical applications, whole blood samples present unique challenges in method development, because of the viscous nature of blood and complexity of its constituents. In this article, we hav...

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Bibliographic Details
Main Authors: Raymond N. Xu, Jill Polzin, Michelle Kranz, Phillip Vaca, Maria Metchkarova, Matthew J. Rieser, Tawakol A. El-Shourbagy
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Pharmaceutics
Subjects:
high throughput analysis
whole blood matrix
liquid chromatography
tandem mass spectrometry
automation
prodrug
incurred sample reproducibility
metabolite
extraction
Online Access:http://www.mdpi.com/1999-4923/2/2/159/

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http://www.mdpi.com/1999-4923/2/2/159/

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